March 3, 2026Open Access

Drug-induced male infertility: a real-world study using FAERS and EudraVigilance databases

Key Points

Male infertility has been linked to 19 high-risk drugs identified in the analysis, including hormonal agents and antidepressants.
The study specifically highlights the importance of risk-stratified fertility counseling for reproductive-age males considering these medications.
Assessment used data from FAERS and EudraVigilance databases to pinpoint risks associated with certain drug classes, especially chemotherapy.
Urgent counseling on sperm cryopreservation is emphasized before administering chemotherapy and certain hormonal treatments.

Abstract

This pharmacovigilance study identified 19 high-risk drugs for male infertility across hormonal agents, antineoplastic drugs, and antidepressants. These findings underscore pre-prescription, risk-stratified fertility counseling for reproductive-age males, prioritizing sperm cryopreservation before chemotherapy and considering it selectively for 5α-reductase inhibitors, testosterone, or antidepressants.

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Authors

Zhuozhi Gong

Jing He

Qiujian Feng

Journals

Frontiers in Pharmacology

Actions

Institutions

Southern Medical University

China Academy of Chinese Medical Sciences

Xiyuan Hospital

References and Citations

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Building similarity graph...

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Drug-induced male infertility: a real-world study using FAERS and EudraVigilance databases

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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