Interferon levels and interferon-stimulated gene expression identify patient subsets with distinct clinical and immunological characteristics in systemic lupus erythematosus

Key Points

• Increased interferon levels are linked to distinct clinical traits and immune responses in systemic lupus erythematosus.
• A significant correlation was found between IFNα levels and disease activity, measured by the SLEDAI score.
• Assessment of IFN pathways at both protein and gene expression levels provides insights into SLE's clinical heterogeneity.
• The identification of biomarkers may enable better disease monitoring and personalized treatment strategies for patients.

Abstract