Identification of maturity-onset diabetes of the young through targeted next-generation sequencing in Thai patients with atypical diabetes in real-world practice

Genetic testing for monogenic diabetes in a real-world setting identified disease-causing variant in 12.1% of young Thai patients with atypical diabetes. Despite this low yield, accurate genetic diagnoses improved clinical management in both probands and family members. These findings underscore the potential contribution of a strong polygenic background or yet unidentified MODY-X genes among Thai patients. Establishing a register of family-based cohorts documenting the molecular diagnosis of atypical diabetes will advance diagnosis and treatment.