Characteristics and functions of the gut microbiome in monozygotic twins with autism spectrum disorders of varying severity

Key Points

• Children with severe autism spectrum disorder exhibit distinct gut microbiota structures, indicating potential therapeutic targets.
• Severe ASD is linked to enriched levels of Porphyromonas and reduced gene expression related to carbohydrate metabolism.
• Assessment of gut microbiota involved analyzing the impact on functional impairments, focusing on stress responses.
• Findings highlight a potential connection between microbial dysregulation and the severity of autism spectrum disorder, warranting further investigation.

Abstract