Guilu Erxian Glue combined with Wuzi Yanzong Pill attenuates granulosa cell apoptosis and ameliorates cyclophosphamide-induced diminished ovarian reserve via the lncRNA NEAT1/miR-204-5p/ESR1 axis

Key Points

• Granulosa cell apoptosis decreases significantly, enhancing ovarian reserve under cyclophosphamide treatment.
• Apoptosis reduced by over 40% following treatment with a combination of two herbal formulations.
• Assessment using molecular analysis highlights the lncRNA NEAT1/miR-204-5p/ESR1 axis as a crucial regulatory pathway.
• These findings support further exploration of herbal interventions in managing ovarian dysfunction.