Mechanistic study of fibroblast-derived extracellular vesicle miR-25-3p targeting TAF15 to inhibit NF-κB activation and alleviate knee osteoarthritis progression in mice

Key Points

• Inhibition of NF-κB activation is observed, contributing to the alleviation of knee osteoarthritis symptoms.
• Key findings include the specific role of miR-25-3p, providing insight into its mechanistic function in knee osteoarthritis progression.
• Assessment of fibroblast-derived extracellular vesicles demonstrates their impact on TAF15 and subsequent NF-κB regulation.
• This study highlights potential therapeutic targets to mitigate knee osteoarthritis, although further validation is required.