Targeting Mycobacterium tuberculosis GAPDH elicits potent bactericidal responses by dysregulating enzyme activity, redox dynamics and iron acquisition

Key Points

• Potent bactericidal responses were observed due to dysregulated enzyme activity and iron acquisition.
• Dysregulation of redox dynamics appeared to enhance therapeutic effects against Mycobacterium tuberculosis.
• Assessment using enzyme activity and redox dynamics across various cellular models supports these findings.
• This approach may enable novel strategies for combating drug-resistant Mycobacterium tuberculosis infections.