Pro-Tumorigenic Roles of Cyclin Dependent Kinase 2 and its Associated Cyclins in Cholangiocarcinoma Progression under High Glucose Condition

Key Points

• Cholangiocarcinoma progression correlates with cyclin dependent kinase 2 activity under high glucose.
• High glucose condition promotes tumor growth, highlighting a new metabolic perspective on treatment.
• Analysis of cellular mechanisms reveals interactions between cyclin dependent kinase 2 and cyclins.
• These findings may lead to targeted therapies focusing on glucose metabolism in cholangiocarcinoma.