Quantitative discometry: Low-dose concordant pain onset identifies sensitized annular nociceptors under pressure–volume–controlled provocation

Key Points

• Pain onset is identified through low-dose provocation, indicating the response of sensitized nociceptors.
• The study employs a quantitative discometry approach to evaluate the relationship between pressure and pain.
• Results highlight the significant role of nociceptor sensitization in pain perception under controlled conditions.
• These findings may enable better pain management strategies and further research into nociceptor functions.