Age-related differences in lipopolysaccharide-induced delirium-like behavior implicate the distinct microglial composition in the hippocampus

Key Points

• Delirium-like behavior differs significantly with age, indicating a potential vulnerability in older populations.
• In aged models, exposure to lipopolysaccharide led to markedly different responses, with microglial activity varying in intensity.
• Analysis using behavioral assessment following lipopolysaccharide administration demonstrated clear age-related trends in hippocampal responses.
• Findings highlight the need for age-specific strategies to address delirium, given the differences in microglial response.