DPhA-EtOBz-TSC targets cystathionine γ-lyase (CSE) to trigger ferroptosis and inhibit colorectal cancer growth in vitro and in vivo

Key Points

• Ferroptosis is induced in colorectal cancer cells, leading to reduced growth rates and viability, indicating potential treatment pathways.
• CSE activity showed significant alterations, demonstrating its role in the ferroptosis pathway affected by DPhA-EtOBz-TSC.
• Analysis using both in vitro and in vivo models confirmed the effectiveness of DPhA-EtOBz-TSC in inhibiting tumor growth and promoting cell death.
• Findings highlight the promise of targeting CSE as a novel approach for treating colorectal cancer, warranting further exploration.