Cerebellar pathological changes in three autopsy cases of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)

Key Points

• Cerebellar changes were identified in all three autopsy cases with adult-onset leukoencephalopathy.
• Prominent findings included axonal spheroids and pigmented glia, indicating specific pathological features.
• Observational analysis of autopsy records showcases distinct cerebellar alterations in the disease.
• Findings support the need for investigations into the mechanisms driving these pathological changes.