Integrated approach to design 5-indolyl-pyrazoles as anti-TB agent

Key Points

• Significant anti-TB activity was observed with the new molecular design targeting tuberculosis.
• Synthesis of 5-indolyl-pyrazoles showed enhancing effectiveness against TB strains with IC50 values around 0.12 μM.
• Integrated approach utilizing both molecular design and pharmacological assessment underscores innovation in drug development.
• Supports the promise of 5-indolyl-pyrazoles as viable candidates for new anti-TB therapies, pushing the boundaries of current treatments.