A role of FURIN in promoting TGF-β signaling activation in MAFLD: Evidence from UK Biobank proteomic cohort

Key Points

• FURIN promotes TGF-β signaling activation, potentially contributing to MAFLD progression.
• Key evidence shows significant proteomic changes linked to FURIN in the UK Biobank cohort.
• Observational analysis across the UK Biobank reveals associations between FURIN levels and TGF-β activity.
• Supports therapeutic exploration of FURIN as a target in treating MAFLD and related conditions.