Neuromodulatory persistent inward current contributes to muscle force reduction and recovery after prolonged bed rest in young and older adults

Key Points

• Muscle force reduction occurs after prolonged bed rest, affecting both young and older adults.
• Recovery dynamics vary significantly between age groups, with older adults showing more pronounced effects.
• This analysis utilized measures of neuromodulatory inward currents to assess physiological responses to inactivity.
• Findings highlight the need for targeted rehabilitation strategies to mitigate muscle force loss due to bed rest.