Seneca Valley virus 2B and 3 C proteins attenuate the cGAS-STING signaling pathway by targeting STING for degradation

Key Points

• Attenuation of cGAS-STING signaling occurs through targeted degradation of STING by viral proteins.
• The investigation primarily focuses on two viral proteins, 2B and 3C, and their effects on cellular signaling.
• Analysis of protein interactions indicates that Seneca Valley virus effectively disrupts the immune response.
• These findings highlight potential viral mechanisms for evasion, calling for further research into viral-host interactions.