AlphaMissense pathogenicity scores predict response to immunotherapy and enhances the predictive capability of tumor mutation burden

Key Points

• AlphaMissense pathogenicity scores significantly predict responses to immunotherapy among various tumors.
• The study highlights the improved predictive capability of tumor mutation burden alongside AlphaMissense scores.
• Observational analysis utilized established genomic databases to assess tumor genomic characteristics and treatment efficacy.
• This investigation supports the integration of AlphaMissense scoring in clinical settings for personalized cancer therapies.