Transplantation of Skin-Derived Precursor Schwann Cells Ameliorates Secondary Brain Injury after ICH in Mice by Activating the PI3K/AKT/FOXO3a Signaling Pathway

Key Points

• Transplantation of skin-derived precursor Schwann cells improves recovery from secondary brain injury after intracerebral hemorrhage (ICH).
• Mice receiving the transplant demonstrated significant activation of the PI3K/AKT/FOXO3a signaling pathway.
• Observational analysis focused on the effects of Schwann cell transplantation in a mouse model of secondary brain injury.
• These findings highlight the potential of Schwann cell therapy as a treatment for brain injury, although further validation is required.