Antimicrobial peptides RI8 and RW8 target bacterial membranes and genomic DNA to overcome drug resistance

Key Points

• RI8 and RW8 significantly reduce bacterial viability, showing great potential against drug-resistant strains.
• These antimicrobial peptides target both bacterial membranes and genomic DNA, revealing a dual-action mechanism.
• Analysis demonstrated that RI8 and RW8's effectiveness spans multiple bacterial species and resistance profiles.
• These findings support further exploration of antimicrobial peptides for combating critical antibiotic resistance.