(‒)-Epicatechin enhances the anti-Acanthamoeba activity of chlorhexidine through synergistic action

Key Points

• Chlorhexidine's activity against Acanthamoeba is significantly enhanced by epicatechin, indicating a strong synergistic effect.
• The study demonstrated an increase in efficacy through molecular pathways activated by the combination of both compounds.
• Assessment involved evaluating the interaction between epicatechin and chlorhexidine against Acanthamoeba in vitro.
• This finding suggests potential improvements in Acanthamoeba treatment strategies by utilizing epicatechin as a co-therapy.