Molecular insights of immune evasion by Orf Virus: the interaction and functional impact of viral OH1 phosphatase on STAT1

Key Points

• The interaction of Orf virus phosphatase impairs STAT1 function, leading to immune evasion.
• Specific inhibitory effects on STAT1 signaling were observed, demonstrating crucial viral strategies.
• Analysis of molecular interactions uncovered how viral phosphatase manipulates immune responses.
• These findings highlight potential therapeutic targets against viral-induced immune evasion.