DBU/H2O: a tunable organocatalytic medium to control the reaction of isophorone with aldehydes at vinylogous aldol addition stage

Key Points

• The experiment demonstrates effective control over the reaction of isophorone with aldehydes.
• Results show a significant adjustment in reaction outcomes when using DBU/H2O as the medium.
• Observational analysis utilized a systematic approach to refine reaction conditions and parameters.
• Highlighting the necessity of advanced mediums in organocatalytic reactions can foster greater efficiency.