Surveillance reveals a prevalent pediatric A(H1N1)pdm09 virus with hemagglutinin substitutions S137P-R142K-V152I that diminish vaccine efficacy

Key Points

• Hemagglutinin substitutions S137P-R142K-V152I significantly reduce vaccine efficacy against A(H1N1)pdm09 virus in children.
• Recent data indicate a prevalence of the A(H1N1)pdm09 virus in pediatric cases correlating with decreased protection.
• Observational analysis reveals key mutations that impact vaccine performance and necessitate ongoing monitoring and updates.
• Further investigations are required to assess vaccine effectiveness against emerging variants in children.