Immune Reconstitution Associated with CMV Reactivation after Discontinuation of Letermovir Prophylaxis - a Prospective Study

Key Points

• CMV reactivation occurs after discontinuing letermovir prophylaxis, indicating immune reconstitution is significant.
• In the study, 30% of patients experienced CMV reactivation within three months post-prophylaxis discontinuation.
• Observational analysis among patients treated with letermovir for CMV showed a connection to immune system recovery.
• Findings highlight the need for monitoring CMV during immune reconstitution after prophylaxis stops.