Cell-Intrinsic and Cell-Extrinsic Mechanisms Determining Allogeneic CAR T cell Expansion and Rejection in Large B-cell Lymphoma

Key Points

• CAR T cell expansion varies based on both intrinsic and extrinsic mechanisms, affecting treatment outcomes.
• Key evidence shows that immune rejection plays a crucial role in the efficacy of CAR T cell therapies.
• Assessment focuses on the interplay between tumor microenvironment and engineered immune cells' behavior.
• Understanding these dynamics may enable better strategies to enhance CAR T cell therapies for patients with lymphoma.