Biomarker Elevations Associated with Immune Effector Cell-Associated Hemophagocytic Lymphohistiocytosis-like Syndrome after CD19-Directed CAR-T Therapy in Children and Young Adults with Acute B-Lymphoblastic Leukemia

Key Points

• Elevated biomarkers indicate the occurrence of hemophagocytic lymphohistiocytosis after therapy.
• Biomarker elevations were observed in children and young adults post CD19-directed CAR-T therapy.
• Analysis of clinical data from leukemia patients highlights important associations with immune responses.
• Findings underscore the necessity for monitoring biomarkers to manage potential complications effectively.