Promethazine provokes behavioral alterations and disrupts redox homeostasis in planarians

Key Points

• Behavioral alterations due to promethazine significantly affect the planarian subjects, impacting their movement and feeding behaviors.
• Promethazine treatment led to notable changes in redox homeostasis along with increased oxidative stress indicators in the planarians.
• Assessment included various behavioral tests and redox state measurements in the aquatic model organism, planarians.
• Findings highlight the effects of promethazine on neurotransmitter systems, raising questions about drug mechanisms and safety.