Evaluating the antibacterial activity of ceftazidime/avibactam and aztreonam combinations against multidrug-resistant Stenotrophomonas maltophilia complex isolates in a hollow fiber infection model

Key Points

• Enhanced antibacterial activity was observed with ceftazidime/avibactam and aztreonam combinations.
• The combination significantly reduced bacterial load in a hollow fiber infection model for multidrug-resistant strains.
• Assessment using a hollow fiber infection model revealed interactions between ceftazidime, avibactam, and aztreonam.
• Findings suggest that this combination may provide effective treatment options against challenging bacterial infections.