Non-enzymatic ABHD6 interacts with Akt-FoxO1 axis to regulate selective hepatic insulin resistance

Key Points

• Selective hepatic insulin resistance is influenced by non-enzymatic ABHD6, affecting metabolic diseases.
• ABHD6 expression increases with obesity and aging, linking it to liver-related conditions.
• The interaction of ABHD6 with the Akt/FoxO1 axis regulates FoxO1 activity, vital for glucose metabolism.
• Potential implications indicate that targeting ABHD6 could provide new avenues for managing liver fibrosis and MASLD.

Abstract