In type 1 diabetes, cardiac autonomic neuropathy and higher BMI are independently linked to reduced corneal nerve fiber length, indicating corneal small-fiber pathology.
Is corneal confocal microscopy associated with cardiac autonomic neuropathy in individuals with type 1 diabetes mellitus?
Individuals with type 1 diabetes mellitus (T1DM)
Corneal confocal microscopy (CCM)
Corneal nerve fiber length (CNFL)surrogate
Corneal confocal microscopy may serve as a non-invasive measure of neuropathy burden, as reduced corneal nerve fiber length is independently associated with cardiac autonomic neuropathy in type 1 diabetes.
In individuals with T1DM, the presence of CAN and higher BMI were independently associated with reduced CNFL. These findings indicate an association between corneal small-fiber pathology and autonomic dysfunction in T1DM, supporting the role of CCM as a non-invasive measure of neuropathy burden, while longitudinal studies are required to determine its diagnostic or prognostic utility.
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Maria Ziori
Anastasios Tentolouris
I. Eleftheriadou
Journal of Diabetes and its Complications
National and Kapodistrian University of Athens
University General Hospital Attikon
Laiko General Hospital of Athens
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Ziori et al. (Sat,) reported a other. In type 1 diabetes, cardiac autonomic neuropathy and higher BMI are independently linked to reduced corneal nerve fiber length, indicating corneal small-fiber pathology.
www.synapsesocial.com/papers/69a76115c6e9836116a2eac5 — DOI: https://doi.org/10.1016/j.jdiacomp.2026.109290