The effects of daily low-dose aspirin on white matter hyperintensity lesions and retinal vascular calibre in healthy older adults: the ENVIS-ion exploratory neuroimaging substudy of the ASPREE randomised clinical trial

Key Points

• Daily low-dose aspirin may influence white matter hyperintensity lesions in older adults, impacting brain health.
• The study highlights that changes in retinal vascular calibre could be linked to low-dose aspirin use over time.
• Exploratory neuroimaging substudy used data from a randomised clinical trial to analyze vascular health outcomes.
• The findings suggest further investigation is needed to evaluate aspirin's effects on neurovascular integrity.

Abstract