Guaiacol counters renal fibrosis via BMP/ERK/Smad1/5/9 signalling in UUO-induced chronic kidney disease

Key Points

• Renal fibrosis significantly decreased with guaiacol treatment, indicating its potential to reverse kidney damage.
• Increased activation of BMP and ERK pathways was observed, highlighting important molecular targets.
• Assessment using in vivo models of obstructive nephropathy demonstrated the role of Smad signaling in this effect.
• Supports further exploration of guaiacol as a promising intervention for chronic kidney disease.