Linagliptin attenuates the adverse effects of a high-sugar diet on insulin sensitivity, hippocampal oxidative stress, and cognitive function in rats

Key Points

• Cognitive function improves with linagliptin treatment, showing promise for reversing high-sugar diet effects.
• Linagliptin leads to a notable reduction in oxidative stress levels—an important marker of cellular damage.
• Analysis using a rat model demonstrated improvements in insulin sensitivity with linagliptin amidst a high-sugar diet.
• Findings suggest linagliptin's potential benefits for metabolic health, though further studies in humans are needed.