Tgfbr2 deficiency promotes mitochondrial dysfunction of vascular smooth muscle cells in thoracic aortic aneurysms and dissections

Puntos clave

• Mitochondrial dysfunction is identified in vascular smooth muscle cells lacking Tgfbr2, complicating thoracic aortic aneurysms.
• Analysis shows Tgfbr2 deficiency correlates with significant impairment in mitochondrial function—affecting smooth muscle cells.
• The study examines thoracic aortic aneurysms and dissections induced by Tgfbr2 deficiency in animal models.
• Highlighting the role of Tgfbr2 in smooth muscle cell function may offer new therapeutic approaches for aneurysms.