Re: Riccardo Bertolo, Antonio Luigi Pastore, Paolo Verze, et al. Real-World Burden and Management of Late Genitourinary Toxicity After Prostate Radiotherapy: Insights from IRRADIaTE, the Italian Registry of Radiotherapy-Associated Disorders and Urological Treatment & Evaluation. Eur Urol Oncol. In press. https://doi.org/10.1016/j.euo.2026.01.005

Key Points

• Late genitourinary toxicity develops in many patients after prostate cancer radiotherapy, impacting quality of life.
• In a comprehensive analysis, 63% of patients reported symptoms such as urinary incontinence and frequency.
• Observational analysis from the IRRADIaTE registry, focusing on real-world experiences and treatment strategies.
• These insights underscore the need for better management protocols to improve patient outcomes after treatment.