Palmitic acid-evoked PKR/JNK activation and SIRT1 decline: Association with myocardial ageing phenotype changes and partial reversal by inhibitors

Key Points

• Activation of the PKR/JNK pathway is linked to changes in the myocardial ageing phenotype.
• Palmitic acid treatment led to a decline in SIRT1 levels alongside increased PKR and JNK activation.
• Inhibitors of PKR and JNK demonstrated potential to partially reverse ageing phenotype alterations.
• These findings highlight potential therapeutic strategies for addressing myocardial ageing.