Intraindividual variability of aldosterone and the aldosterone-to-renin ratio detected by LC-MS/MS and their impact factors in patients with hypertension

Key Points

• Aldosterone variability is linked to hypertension, highlighting its potential role as a cardiovascular risk factor.
• In patients with hypertension, significant fluctuations in the aldosterone-to-renin ratio indicate underlying physiological impacts.
• Assessment using liquid chromatography-mass spectrometry reveals important biomarkers for understanding hypertension.
• Understanding how aldosterone levels change in individuals may direct future hypertension management strategies.