Discovery and structure-activity relationship of cannabidiol aminoquinones as anti-Alzheimer's agents via dual modulation of Nrf2/HO-1 and TLR4/NF-κB pathways

Key Points

• Cannabidiol aminoquinones show potential as anti-Alzheimer's agents by modulating nrf2 and tlr4 pathways,
• the modulation resulted in significant increases in HO-1 expression and decreases in NF-κB activity,
• Assessment using various cell lines revealed the dual pathway modulation as crucial for efficacy,
• findings highlight new therapeutic targets for Alzheimer's, particularly through these specific molecular pathways.