Synthesis and Biological Evaluation of chalcone derivatives of 1,2,4triazolo4,3-apyridines as Anticancer Agents

Key Points

• Chalcone derivatives demonstrated significant anticancer activity against several cancer cell lines.
• The study identified three leading compounds that inhibited tumor growth by more than 50% in vitro.
• Synthesis involved various chemical processes to create triazolopyridine forms, followed by biological evaluations.
• Findings suggest that these compounds may serve as promising leads for developing new cancer therapies.