In vivo confocal microscopic evaluation of patients with epidermolysis bullosa demonstrates severe loss of corneal nerves

Key Points

• Severe loss of corneal nerves was observed in patients with epidermolysis bullosa, highlighting significant ocular surface alterations.
• On average, a notable reduction in nerve density was quantitatively assessed using in vivo confocal microscopy techniques.
• The study utilized in vivo confocal microscopy to analyze the corneal nerves in these patients, providing detailed imagery and measurement.
• These findings suggest that patients with epidermolysis bullosa may experience chronic sensory fiber loss, potentially impacting their quality of life.