7-Ketocholesterol promotes T cell migration through Ca2+-NFATc1 pathway-mediated F-actin polymerization and proinflammatory cytokine production in oral lichen planus

Key Points

• T cell migration is significantly enhanced by 7-ketocholesterol, indicating its role in immune response.
• The study highlights increased expression of proinflammatory cytokines IL1B, CCL4, and IL6 due to this pathway activation.
• Observational analysis indicates that migration is mediated through the Ca2+-NFATc1 pathway and F-actin polymerization.
• These findings underscore the potential importance of 7-ketocholesterol in the inflammatory processes of oral lichen planus.

Abstract