March 3, 2026Open Access

Association of Y-chromosomal gr/gr deletions with testicular germ cell tumor: whole-genome analysis of 198,306 individuals

Key Points

gr/gr deletion status alone is likely not predictive of testicular germ cell tumor risk, further complicating earlier hypotheses.
this analysis covers a significant population scale with 198,306 individuals, highlighting its extensive reach.
the method of whole-genome analysis allows for a comprehensive exploration of genetic factors influencing tumor risk.
further research is essential to understand contributions from other determinants like y-haplogroups and semen traits.

Abstract

Our analysis suggests gr/gr deletion status alone is likely not predictive of TGCT risk in population-scale analyses of European-like individuals; however, the importance of other proposed determinants of gr/gr deletion impact, including Y-haplogroups and semen phenotype, remains unexplored at scale.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Authors

Subin Choi

Maria Santa Rocca

Cinzia Vinanzi

Actions

Institutions

University of Pennsylvania

University of Toronto

University of Minnesota

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Association of Y-chromosomal gr/gr deletions with testicular germ cell tumor: whole-genome analysis of 198,306 individuals

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study