Combination of sodium pentaborate pentahydrate, curcumin and piperine treatment induces ferroptosis in hepatocellular carcinoma cells by regulating iron homeostasis and ROS activity in vitro

Key Points

• Ferroptosis is effectively induced in hepatocellular carcinoma cells through the treatment.
• Key findings reveal significant modulation of iron homeostasis and reactive oxygen species activity.
• Combination therapy includes sodium pentaborate pentahydrate, curcumin, and piperine, enhancing efficacy.
• Potential clinical implications include targeting cancer metabolism through ferroptosis induction.