LncRNA TMPO-AS1 aggravates the cisplatin resistance in cervical cancer via miR-140-5p/DNMT1 axis-mediated DNA methylation of KLK10

Key Points

• Cisplatin resistance increases with higher levels of lncrna TMPO-AS1, impacting treatment efficacy.
• The study identifies a significant decrease in mir-140-5p levels, which suppresses DNMT1 expression.
• Analysis of cellular assays reveals that the alteration in DNA methylation of KLK10 is crucial for this mechanism.
• Further exploration of this axis may lead to innovative strategies for overcoming drug resistance in cervical cancer.