The effects of sofosbuvir on the colon of adult male albino rats and the potential protective role of propolis: A histological and immunohistochemical study

Key Points

• Sofosbuvir exposure leads to significant alterations in colon structure, indicating potential harm.
• Histological analysis shows increased fibrosis and oxidative stress in the colon due to sofosbuvir treatment.
• Immunohistochemical findings reveal changes in key biomarkers linked to neoplasia and inflammation.
• Propolis appears to mitigate some of the harmful effects induced by sofosbuvir, highlighting its protective role.