What does this research mean for the field?

Early cardiac sympathetic denervation occurs in hereditary transthyretin amyloidosis (ATTRv) before clinical symptoms manifest, as indicated by reduced l-H/M ratios from 123 I-mIBG imaging. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 5, 2026

Early cardiac sympathetic denervation in hereditary transthyretin amyloidosis: 123I-metaiodobenzylguanidine findings and correlation with skin biopsy.

Key Result

Reduced l-H/M on 123I-mIBG indicates early cardiac sympathetic denervation before symptoms in hereditary ATTR amyloidosis; combining with skin biopsy improves early detection.

Key Points

To investigate early cardiac sympathetic denervation in hereditary transthyretin amyloidosis using advanced imaging and biopsy techniques.
Analyzing l-H/M ratio from <sup>123</sup>I-mIBG imaging
Performing skin biopsies for corroborative assessment
Correlating imaging findings with clinical symptoms
Reduced l-H/M ratio indicates early cardiac sympathetic denervation
Skin biopsy findings support enhanced detection of cardiac issues
Combined <sup>123</sup>I-mIBG and skin biopsy methods improve risk stratification

Structured PICO

Does combined 123I-mIBG imaging and skin biopsy improve early detection and risk stratification in hereditary transthyretin amyloidosis?

Population

Patients with hereditary transthyretin amyloidosis (ATTRv) and asymptomatic carriers (AC)

Intervention

123I-metaiodobenzylguanidine (123I-mIBG) imaging and skin biopsy

Outcome

Early detection of cardiac sympathetic denervation and risk stratificationsurrogate

Combined 123I-mIBG imaging and skin biopsy can detect early cardiac sympathetic denervation in asymptomatic carriers of hereditary transthyretin amyloidosis, improving risk stratification.

Abstract

Reduced l-H/M indicates early cardiac sympathetic denervation in AC, preceding clinical symptoms. Combined 123I-mIBG and skin biopsy improves early detection and risk stratification in ATTRv.

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Discussion

Authors

Viviana Frantellizzi

Chiara Cambieri

Eleonora Galosi

Actions

Institutions

Sapienza University of Rome

Istituti di Ricovero e Cura a Carattere Scientifico

Università Cattolica del Sacro Cuore

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Building similarity graph...

Analyzing shared references across papers

Early cardiac sympathetic denervation in hereditary transthyretin amyloidosis: 123I-metaiodobenzylguanidine findings and correlation with skin biopsy.

Key Result

Key Points

Structured PICO

Abstract

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Connected Papers

Discussion

Authors

Actions

Institutions

References and Citations

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Discussion

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