What question did this study set out to answer?

The central aim is to determine how SPECT imaging can aid in distinguishing between language-predominant Alzheimer's disease and other types of primary progressive aphasia.

March 8, 2026

Eligibility for Anti-Amyloid-β Monoclonal Antibodies in Patients With Primary Progressive Aphasia due to Alzheimer's Disease in Japan.

Key Points

The central aim is to determine how SPECT imaging can aid in distinguishing between language-predominant Alzheimer's disease and other types of primary progressive aphasia.
Examined the role of SPECT imaging in diagnosis.
Focused on patients with language-predominant symptoms.
Compared cases of language variant Alzheimer's disease (lvAD) with primary progressive aphasia (PPA).
SPECT may effectively support differentiation between lvAD and PPA.
Accurate identification of lvAD is critical for appropriate treatment options.

Abstract

These results suggest that SPECT may play a supportive role in differentiating lvAD from PPA. In the current clinical era of anti-amyloid-β monoclonal antibody therapy, accurate identification of lvAD among patients with language-predominant symptoms is increasingly important. Larger studies should be performed in the near future to validate these findings.

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Discussion

Authors

Shoya Inagawa

Yuta Inagawa

Akito Tsugawa

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Institutions

Niigata University

Tokyo Medical University

National Center for Geriatrics and Gerontology

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Eligibility for Anti-Amyloid-β Monoclonal Antibodies in Patients With Primary Progressive Aphasia due to Alzheimer's Disease in Japan.

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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