Aspartyl-tRNA synthetase 1 (DARS1) reshapes hepatocellular carcinoma proteome and promotes aggressiveness through non-canonical SAGA–MYC signalling modulation

Key Points

• The study aims to investigate the role of DARS1 in hepatocellular carcinoma aggressiveness and its potential as a biomarker.
• Analyzed DARS1 expression in hepatocellular carcinoma samples
• Examined DARS1's impact on the proteome
• Investigated non-canonical interactions with the SAGA complex and MYC
• DARS1 is overexpressed in hepatocellular carcinoma tissues and detectable in plasma
• Alterations in the proteome linked to DARS1 activity increase cancer aggressiveness
• Non-canonical interactions with the SAGA complex modulate MYC signaling

Abstract