Prophylactic para-aortic irradiation vs pelvic radiotherapy in pelvic node-positive carcinoma cervix in the setting of concurrent chemoradiation: a phase II open-label multi centric randomized controlled trial (PRO-PARA)

Puntos clave

• The trial aims to compare the effectiveness of prophylactic para-aortic irradiation to pelvic radiotherapy in patients with pelvic node-positive cervical cancer during concurrent chemoradiation.
• Conducted as a phase II open-label multi-centric randomized controlled trial
• Participants were randomly assigned to receive either prophylactic para-aortic irradiation or pelvic radiotherapy
• Evaluated treatment effectiveness based on clinical outcomes
• Findings indicated differences in treatment outcomes between the two radiotherapy approaches
• Results will help guide recommendations for managing pelvic node-positive cervical cancer

Resumen