A Straightforward Synthesis of N‐Substituted Amino Acid Steroid Lactones via Pd‐Catalyzed Three‐Component Reactions of Steroid Enol Ethers, Glyoxylic Acid, and Anilines

Key Points

• The research aims to synthesize N-substituted amino acid steroid lactones using palladium-catalyzed reactions.
• Pd-catalyzed cycloaddition of α-iminocarboxylic acids and steroid enol ethers was performed.
• Steroid enol ethers and glyoxylic acid were key reactants in the reaction.
• Single diastereomer production was targeted due to specific steric hindrance.
• A single diastereomer of amino acid steroid lactones was produced.
• High diastereoselectivity was noted due to steric factors around the enol ethers.
• The endo mode of cycloaddition predominated, explaining the results.

Abstract